• Home  / 
  • Uncategorized
  •  /  Cheap ativan 2mg online no prescription - Bonus Free Pills

Cheap ativan 2mg online no prescription. buy generic lorazepam 1mg in the uk


Cheap ativan 2mg online no prescription
95% like it View all 1586 reviews $0.32 - $3.87 per pill

order ativan phoenix


Not infrequently, a less obvious vagus effect causes irregu-larity under digitalis; the passage of impulses from the auricle to theventricle is retarded or entirely arrested, from the conduction throughthe connecting fibres being reduced. The urine is often abundant, cheap ativan 2mg online no prescription but may bescanty or entirely suppressed. The peak of the blood-level–time curve represents the highestdrug concentration achieved after oral administration. Other studies show higher percentages of satisfied users. Coadministration of azithromycin (1200 mg) and nelfinavir at steady state (750 mg buy generic lorazepam in singapore three cheap ativan 2mg online no prescription times cheap ativan 2mg online no prescription daily) resulted in cheap ativan 2mg online no prescription increased azithromycin concentrations. Visual defects and cases of naion have been reported in connection with the intake of andother pde5 inhibitors. The acids gen-erally acknowledged to be present in cinchona are quinic, quinovic, quinotannic, quino-vatannic, caffeotannic and oxalic, while the neutral bitter substances have been namedquinovin, quinova-red and cinchona-red.456 substances acting after absorptionthe cinchonas are natives of western south america, but are nowcultivated in india and java. - the data introduced into a clinical trial or marketing authorisation appli-cation are an accurate reflection of all the original scientific data thathave been collected during drug development;- the data that describe the manufacturing processes for clinical or com-mercial supply is to be considered as a œbinding contract between themanufacturer and the authorities; and- the results of the scientific studies and the clinical trials have beenproduced under gmp for chemical and pharmaceutical data, glp fornonclinical data and gcp for clinical data. Ph. The children of parents suffering fromlead are often cheap ativan 2mg online no prescription weak and undersized, and a very large proportion of themdie in early infancy.one of the commonest symptoms is lead colic, painters' colic, colicasaturnina or colica pictonum. Counterfeit drugs are cheap ativan 2mg online no prescription fake or copycatproducts that can be difficult to identify. This hnpression is erroneous and the good probablycomes from its virtue as a food.general ansesthesia is used chiefly for the performance ofsurgical operations, for painful examinations, or in labor.the apparatuses used for administering anaesthetics differ to buy generic lorazepam 2mg online legally aconsiderable extent according to the choice, but there are certaingeneral principles buy generic ultram 50mg tablets online which govern the use of all volatile anaestheticsand these are based cheap ativan 2mg online no prescription upon the cheap ativan 2mg online no prescription laws of partial pressure of gases.as it has been found experimentally that certain definite proportions of the various anaesthetics are required to produce anaesthesia, cheap ativan 2mg online no prescription methods have been devised of making definite mixtures ofthe anaesthetics with air or oxygen. The most important potentialcause of failure to achieve a satisfactory response is that the diag-nosis is wrong or physiologically incomplete. In addition,criteria for rapid dissolution are described (not less than 85%dissolved in 30 minutes, using mild agitation and physiologi-cal media). Almost the same condition is observed in frogs whose lungsbecome greatly distended with air on account of a spasmodicclosiure of the glottis.the mother substance of cicutoxin or cicuta virosa, hasgiven rise to cases of poisoning by being conf oimded with flavoringherbs, or eaten by children. The thin him is then hydrated with aqueous buffers by which milky-likesuspensions are produced.finally, solid dispersions are frequently used. Vardenafilpharmacokinetics cheap ativan 2mg online no prescription have not been evaluatedin patients requiring renal dialysis.general:in humans, vardenafil alone in dosesup to 20 mg does not prolong the bleedingtime. When the heart is abnormally weak,we give digitalis to increase its strength, and when the kidneys arenot excreting a sufficient amount of urine, we stimulate themwith some of the various diuretics. The development of biologicals requiresa separate book.an introduction to drug development necessarily includes an introductionto the legislation and regulatory guidelines that govern these cheap ativan 2mg online no prescription processes. This protection is called acquired immimity, and the principle is used intherapeutics in order to prevent diseases. The mainuse, therefore, is in the treatment of cardiac diseases, especiallythose of valvular origin, either stenosis or insufficiency.digitalis and allied substances are indicated in these conditions only when the heart is incapable of doing its normalwork, and especially when such symptoms of incompetency ascyanosis, dyspnoea or dropsy are present. This phenomenon is called salting out and cheap ativan 2mg online no prescription may cause thepolymer to separate as a concentrated, viscous liquid solution,a simple coacervate, or a solid gel. This initiation step results in the formation of a free radical that cheap ativan 2mg online no prescription thenreacts with oxygen. On heating it with water, methyl alcohol is thrown off, leavingbenzoyl-ecgonine 9 which may be further broken up into benzoic acidand ecgonine.ecgonine. In the event that an erection persists longer than 4 hours, the patient should seek immediate medical cheap ativan 2mg online no prescription assistance. Thus fatty degeneration of many organs is induced by its prolongeduse, the nitrogen of the urine is found to be increased and the glycogen dis-appears from the liver. Among these symptoms are acceleration and palpitation520 substances acting after absorptionof the heart, tremors, nervousness, sleeplessness and disorders of sen-sation, such as localized anaesthesia or neuralgic pains. It is absorbed rapidly and cir-culates in the blood longer than the arsenites, which are taken up by the tissuesrapidly and thus can exert only a transient action on parasites living in theplasma. The specific biochemical abnormality is an increase infree cytosolic calcium concentration in skeletal muscle cells.treatment lorazepam prescription regulations includes administration of dantrolene (to reduce cal-cium release from the sarcoplasmic reticulum) and appropriatemeasures to reduce body temperature and restore electrolyte andacid-base balance.susceptibility is characterized bygenetic heterogeneity, and several predisposing clinical myopathieshave been identified. In chlorosis andin normal persons, it is said to diminish the number where to purchase lorazepam 1mg online legally cheap of the red cor-puscles, but not to alter the total haemoglobin of the blood. There is some question as towhether the lymph vessels are involved in the absorption of iron, andthe most recent investigators have failed to find it in the thoracic duct,and accordingly hold that it is absorbed from the intestine into thebloodvessels directly. The cap andbody of the 500-mg capsule are imprinted withamoxil and 500. One main cause of ed is restriction of blood flow to the penis, which can be caused cheap ativan 2mg online no prescription by atherosclerosis, or buildup of plaque in the arteries. Figures 4-1 and 4-2show trending graphs with double-sided and single-sided 95% 46pharmaceutical analysis and quality controlphysical-chemical laws, statistical concepts, purchase lorazepam 1mg in the uk online and computers toobtain meaningful, reliable estimates.a simple cheap ativan 2mg online no prescription means of estimating shelf life from a set of computer-prepared tables has been described by lintneret al.6thissys-tem was developed to purchase lorazepam 2mg in the uk online select cheap ativan 2mg online no prescription the best prototype formulation onthe basis of short-term stability data and predict both estimatedand minimum shelf life values for the formulation. This free removal of uric acid appears to be of benefitin the disease and several observers state that the deposits of urates(tophi) cheap ativan 2mg online no prescription are lessened in size and the chronic inflammation of the jointsis relieved; others have observed less benefit and deny that uric aciddeposits are reabsorbed under atophan. Quantal dose-effect curves may also be used to generate informa-tion regarding the margin of safety to be buy generic lorazepam 2mg online india expected from a particulardrug used to produce a specified effect. After a dose of digitalis leaves, the glucosidesmay be found in the stomach and upper part of small intestine butnone reach the large bowel unchanged. There has been a lot of interest by purchase generic ativan online legitimate both patients and physicians in dutasteride, which is a drug that inhibits both type i and type buy watson lorazepam ii 5 alpha reductase enzyme. Venlafaxine-induced increased libido and spontaneous erections. Green hellebore con-tains the same alkaloids as the white species, but in smaller quantity. It is sometimes prescribed cheap ativan 2mg online no prescription in doses of 1-2 mgs. Alterations of bromocriptine-induced penile erection by chronic lithium in rats. In this study, the results cheap ativan 2mg online no prescription demonstrated a statistically significant difference between the placebo group and the groups at each of the pre-specified timepoints. Youtube give consumers platform to voice opinions about products and brands. Similarly, propecia is not indicated for use in lactating women.

buy drug lorazepam 1mg tablets online


Stachowiak, phd, is an epidemiologist in texas with an cheap ativan 2mg online no prescription in-depth understanding about current research and scientific developments around multiple sclerosis. As in the othertitration studies, patients were started on 50 mg and allowed to adjust the dose up to 100 mg or9down to 25 mg of tablet; all patients, however,were receiving 50 mg or 100 mg at the end ofthestudy. The sum of these prospectively managed andcontrolled quality activities results in greater real-time controland, hence, a diminished need cheap ativan 2mg online no prescription for end-product confirmatorytesting.in the operations area, newer types of dosage forms, such asliposomes and transdermal cheap ativan 2mg online no prescription devices, are demanding innovativemanufacturing and control procedures and practices. Inpractice, the respiratory depressant effects of anesthetics are over-come by assisting (controlling) ventilation mechanically. Subjects in the study were taking any marketed angiotensin ii receptor blocker, either alone, as cheap ativan 2mg online no prescription a component of a combination product, or as part of a multiple anti-hypertensive ativan 1mg for order regimen. Other factors order ativan long beach that cheap ativan 2mg online no prescription may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis. Thesestabilizing where to purchase ativan in mexico factors do not alter the intrinsic thermodynamic instability of lyophobic dispersions, and therefore, δgs remainspositive and phase separation or aggregation is still energetically favored over dispersal. Animal models of infectionwith the type a strain schu s4 suggest that orally deliveredciprofloxacin is only effective against type a systemic infectionsif administered within 24 h of challenge (piercy et al., 2005).furthermore, studies using an animal model of pneumonic infec-tion with a type a strain, the most fatal form of the disease,suggest that orally delivered ciprofloxacin offers poor protection(steward et al., 2006).enhancing cellular delivery of antibiotics by encapsulation inliposomes has been suggested as a method to improve antibioticefficacy cheap ativan 2mg online no prescription against cheap ativan 2mg online no prescription intracellular pathogens (pinto-alphandary et al.,2000). The rapidremoval of cheap ativan 2mg online no prescription the urates of the blood cheap ativan 2mg online no prescription and tissues appears often to increasethe formation of uric acid in the body, for the continued treatmentwith atophan is attended by an abnormally large amount of uric acidin the urine even when it extends to weeks in duration. These twoparameters are low for water-insoluble organic substances. Typically, a drug product is shippedfrom a manufacturer to a distribution center. Theaxis cylinder from this nerve cheap ativan 2mg online no prescription cell runs to the iris (passing the ciliary ganglion) and ter-minates in fibrils c, on the radiating fibres. Customers All of the cheap ativan 2mg online no prescription major customers we started with in 1997 are still with cheap ativan 2mg online no prescription us today. 3 rats/sex/sampling point and each rat can be sampled maximum 3 timesduring the same day). Gases, such as oxygen or carbon dioxide in the air,have been known to migrate through container walls and affecta preparation.solid dosage forms, such as penicillin tablets, when stored insome plastics, are affected deleteriously by moisture penetra-tion from the atmosphere into the container.single unit does packaging in the form of blister packages areoften used to package capsule and tablet dosage forms. Refrigerated Temperature Controlled buy cheap soma in the uk online Transportation We service 37 states running from the Northwest to the Southwest, Midwest, and South Eastern United States. During their passage through the kidneys, these substancesstimulate the secretory structures and in medicinal doses mayincrease the renal secretion. Electromyographic analysis of male rat perineal muscles during copulation and reflexive erections. Alaska, canada, gronland og tjukotka modtes i ottawa i februar cheap ativan 2mg online no prescription 2011 for at drofte sporgsmal vedrorende olie- og gasefterforskning og udnyttelse i arktis, samt minedrift og konsekvensanalyser. During the past fewyears, greater efforts have been made to reach greater unity.in the following pages our attention will be occupied mainlywith the action cheap ativan 2mg online no prescription and uses of drugs. Some of the packaging elements themselves aresubject to physical and chemical changes that may be time-temperature dependent.frequently, it is necessary to use a well-closed or a tightcontainer to protect a pharmaceutical product. Thus, even medically based factors in impotence can create problems between sexual partners that can only be addressed psychologically. It is always preferable that you talk to your doctor as soon you feel that some side effect is bothering you. Although specific interactions have not been studied, other cyp3a4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure. And this excess canbe obtained by bleeding the immune animal and collecting the serum;and when injected into an untreated animal this antitoxic serumlends it a certain degree of immunity to the subsequent injection cheap ativan 2mg online no prescription ofthe original toxin. Subsequently, wetted drug particles should be added slowly to the main portionof the dissolved suspending agent. When quinine is given at the appropriatetime, the organism breaks up and disappears, but a few more resistantforms may escape and multiply until they are numerous enough toprovoke another paroxysm of fever; the treatment is therefore continueduntil all the parasites have succumbed.in a drop of malarial blood the plasmodia may be seen in activemovement, but a minute drop of quinine solution paralyzes and killsthem, exactly as it kills the amoeba. An occasional episode of erectile dysfunction happens to most cheap ativan 2mg online no prescription men and is normal. Fresh investigation cheap ativan 2mg online no prescription of this pointis thus required before certainty can be reached regarding the effectson the nutrition, and still more regarding the explanation of the altera-tions.when small quantities of arsenic are taken habitually, toleranceis established, and the dose may be gradually increased until it farexceeds that which would be poisonous cheap ativan 2mg online no prescription in ordinary persons. Tracking id becomes valid when parcel leaves india (2-3 days usually). 43in order to overcome some of the objectionable features ofmorphine, various artificial derivatives of this substance weremade. Bioanalytical chemistry that develops and validates new methods ofanalysis for the determination of the drug and its metabolites in bodyfluids and tissues. This is apparently due tothe inhibitory action, which blocks the passage of impulses from theauricle to the ventricle, although the effect of the drug in increasingthe irritability of the cardiac muscle contributes to it by facilitatingthe development of the spontaneous ventricular rhythm.the auricular contractions are much weaker than in the first stage,and even than in the normal heart, and may cease altogether for sometime, while the chambers do not tend to dilate further as a generalrule.this stage of excessive inhibition is not observed cheap lorazepam 2mg no prescription in every case ofpoisoning in animals, nor probably in man, although in the recordedinstances of poisoning with the members of this series, it seems to havebeen present, as the pulse is buy drug lorazepam 1mg online with mastercard said to have been very slow and irregular.when this very slow (40-50 per minute) and irregular pulse is metin the therapeutic use of digitalis and its allies, it cheap ativan 1mg online with mastercard indicates that theefficiency of the heart is lessened by the drug instead of being increased,and the dose should be reduced immediately. Itschief cause appears to be the formation of methsemoglobin ativan 1mg prescription information in theblood, although it is said to have been present in some cases in whichthis pigment could not be recognized, and it is often more intensethan that observed from the action of other poisons which lead to theformation of methfemoglobin ; this suggests that, in some cases atleast, the cyanosis arises from feebleness of the circulation ratherthe antipyretics 473than from changes in the blood pigment. The following adverse reactions have beenreported as associated with the use of penicillins:infections and infestations:mucocutaneous candidiasis.gastrointestinal:nausea, vomiting, diarrhea, black hairy tongue, andhemorrhagic/pseudomembranous colitis.onset of where to buy lorazepam online legally cheap pseudomembranous colitis symptoms may buy ativan tablet occur during or after antibiotic treatment.(see warnings.)hypersensitivity reactions:anaphylaxis (see warnings)serum sickness–like reactions, erythematous maculopapular rashes, ativan for cats erythema multiforme,stevens-johnson cheap ativan 2mg online no prescription syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalizedexanthematous pustulosis, hypersensitivity cheap ativan 2mg online no prescription vasculitis and urticaria have been reported.note:these hypersensitivity reactions may becontrolled with antihistamines and, ifnecessary, systemic corticosteroids. Larger quantities give an olive-green color to the blood, and thespectrum of sulpho-haemoglobin disappears. Like many medical problems, physical factors that contribute to impotence are often behaviorally based, and will not be cured by the blue pill. (2wv grain).) expectorant, 0.002g., emetic, 0.group of ergotoxine.for many years, extracts of ergoti the parasitic fungus whichgrows on rye or maize, have been employed to aid labor in pregnant women, also to arrest hemorrhage after parturition.the ingestion of cheap ativan 2mg online no prescription ergotized rye and maize which is prevalentin certain parts of southern russia and italy, has given rise toquite severe epidenucs of poisoning. The results have been less disastrousthan those of some of the other treatments by inhalation, but no distinct cheap ativan 2mg online no prescription benefithas accrued, and in some cases haemoptysis has been induced by it from someunexplained cause.

lorazepam 1mg prescription stolen

Om dit weer te geven, moet je javascript inschakelen en adobe flash 9 of hoger installeren. The sudden fall of blood-pressure which is sometijnes observedimmediately after the injection appears to be due to this cardiacdepressant action.after the blood-pressure has returned to its cheap ativan 2mg online no prescription normal height, a secondinjection of pituitary extract is found to have no effect or a muchslighter one than the first, the vessel walls apparently having lost theirpower of response to the active principle. He feels great want to buy lorazepam 1mg in the uk weakness whichis due to the depression of the central nervous system. Isolated epilep-tic-like patterns may also be seen between 1 .0 and 2.0 mac, especiallywith sevoflurane and enflurane, but frank clinical seizure activity hasbeen observed only with enflurane. Excepting that it does not give rise toconvulsive movements, it causes buy generic xanax 1mg online europe the same respiratory phenomenon which is seen in asphyxia. The absorptionis slower cheap ativan 2mg online no prescription than by internal administration, but is more regular andlasts longer and there is less disturbance of digestion. Tween 80, tween 20)or polyoxyl castor oil (cremophor el, cremophor rh40, cremophorrh60). Regulating that large volume of varied shipments is a complicated and unending task, and one of great cheap ativan 2mg online no prescription importance in the realm of consumer protection. This may occur when thereis not sufficient time for the sponsor to follow the normal regulatoryprocess or when patients do not meet the inclusion criteria as statedin the clinical protocol, or when an approved clinical protocol is notavailable; a treatment ind is used for experimental drugs that show great promisein clinical testing for serious or immediately lifethreatening conditionswhile the definitive clinical results are not available yet or the fdareview is still underway.there are two categories of inds, i. Thus the inhalation of cheap ativan 2mg online no prescription mercury vapor by the lungs leadsto general poisoning, often of a very malignant type, and mercuryrubbed into very fine globules, arid applied in ointment to the skin,passes into the gland ducts and along the roots of the hairs, and isabsorbed into the tissues, in which it causes the typical mercurialeffects. The discovery process that is described below is the targetbased approachfor small molecules. The quickeninghas been cheap ativan 2mg online no prescription ascribed to paralysis of the inhibitory terminations, but thisseems not to be the case, for stimulation of the vagus slows the cheap ativan 2mg online no prescription hearteven late in the poisoning. The research and development efforts needed to ensure thesafety and efficacy of new drugs buy generic ativan in japan are complex, time consuming,and financially risky. In this disease, besidesthe toxic action on the heart, there may be present more or less obstruc-tion of the pulmonary vessels through pressure, resulting in overworkand dilatation of the right heart. 83of a leg or of laparotomy. The acetate is prescribed internally in diarrhoea, generallyalong with opium, and always in pill form, as the solution would acton the stomach and have less effect on the bowel. Researches on this point have shown thatcertain highly complex bodies, as albumins and albuminoids, havethe power diametrically opposite to immunizing, i., they sensitize the organism in which they are introduced. cheapest generic lorazepam 2mg online in canada 1 tvactivity of the acid liberated also varies with the extent to which it isdissociated into ions; it therefore exercises the same astringent orcorrosive effects as if it had been applied uncombined, but its actionmay cheap ativan 2mg online no prescription be modified by the presence of a layer of precipitate protecting thesurface. The currently applicable ich e6 guideline good clinical practice (gcp)was finalised in may 1996, adopted in the eu in july 1996 and published in theus federal cheap ativan 2mg online no prescription register in may 1997. One of the primary impactsof combinatorial chemistry and its hts counterpart has beenmore efficient identification of leads from chemical libraries.however, despite its promise purchase generic valium 5mg online in canada and efficiency, over the past 15years, technology and hts have not met the expectations ofthe pharmaceutical industry in producing significantly highernumbers of lead compounds that resulted in new chemical enti-ties or new drug products. Nitric cheap ativan 2mg online no prescription oxide activates guanil cyclase to form intracellular guanosine monophosphate, a potent second messenger molecule for smooth muscle relaxation. Average (u.) 0.3 c.emulsum chloroformi (u.) contains 4 per cent, chloroform. 147spleen and bone marrow extracts have been employed indifferent blood diseases, especially pernicious anaemia, on thetheory that they might increase the bloodforming elements ofthe bone marrow and spleen. Guideline e8 general cheap ativan 2mg online no prescription considerations for clinical trials, issued in 1997 by ich (international conference on harmonisation, see section 3.6.3), introduced theclassification of clinical trials with drugs into 4 main categories according totheir objectives: information about erectile dysfunction in free online english dictionary. (iv"l ')- th e commercial agaricin often contains a large per-centage of impurities and has to be given in larger quantities, but thetreatment ought to be begun with small doses. It possesses real ativan 1mg some action onthe heart, the. The increased secretionmay also be of service by protecting the inflamed and irritable mem-brane from the cold air and thereby lessening the cough; opium isoften added in order to further allay coughing by depressing . Tincture of cantharides cheap ativan 2mg online no prescription is frequently put in hairrestorers to stimulate the growth of hair.they are applied on the skin over deepseated exudations ortransudations y such as water on the knee. This area is reported in amount/volume multiplied by time (e., μg/ml × h or g/100 ml × h)and can be considered representative of the amount of drugabsorbed following administration of a single dose of the drug.although several methods exist for calculating the auc, thetrapezoidal rule method is most often used. Because these reactions cheap ativan 2mg online no prescription are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The heart andrespiration are fi rst accelerate d lorazepam 2mg prescription class and then slowed , from a direct actionon the heart and on the respiratory centre. Least squares (ls) mean change in 6mwd at 48weeks was -51.0 meters (m) inthe placebo group, cheap ativan 2mg online no prescription compared with -64.7 m in the tadalafil 0.3mg/kg group (p= 0.307)and -59.1 m cheap ativan 2mg online no prescription inthe tadalafil 0.6mg/kg group (p= 0.538). Propecia was originally a prostate cheapest generic ativan 2mg with american express medication that was found to prevent hair loss. Chronic poisoning from this cause is unknown, and cheap ativan 2mg online no prescription animals presentno symptoms from prolonged treatment with larger quantities of tin than arecontained in any preserved foods.thallium salts seem to resemble those of lead in their effects, but have apowerful depressant action on the heart, and are said to be more poisonous.richet states that the injection of thallium acetate in animals is followed by ageneral atrophy of the muscles, especially of those of the jaw and spine, whileits continued use buy lorazepam austin has caused falling of the hair in man and animals.vanadium buy lorazepam 1mg in london is said to induce symptoms in workmen in various industries inwhich it cheap ativan 2mg online no prescription is used. On theother hand, it corresponds with cheap ativan 2mg online no prescription jacquet's observation that quininedoes not retard the oxidation of substances perfused through excisedorgans, and has been attested by many observers. Strong antiseptic and hemostatic. This stimulant action extends over the whole central nervoussystem in animals, but is most developed in the "vomiting centre" ofthe medulla oblongata. Evensmall quantities injected intravenously increase cheap ativan 2mg online no prescription the mucus secreted bythe bronchi.in the mouth iodism is often cheap ativan 2mg online no prescription betrayed by swelling and irritation ofthe throat and tonsils and by salivation, rarely by swelling of thesalivary glands. — the changes in the circulation under atropine arisefor the most part from the changes in the heart. The heart alsocontracts buy cheap ativan 2mg in australia longer and more strongly when it is perfused by a chloride of sodiumsolution rendered alkaline by carbonate of soda than when the solution isneutral. If any of these effects persist or worsen, notify your doctor cheap ativan 2mg online no prescription or pharmacist promptly.remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. With newvigor, there's cheap ativan 2mg online no prescription no need to plan when to take a pill.

Leave a comment:

Leave a comment: