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The pulse is accelerated, the respiration is quick and deep,the pupil generally dilated, and headache and dryness of the throatare complained of. An overview of the constituents of a qmsis given in table good practicesthe focus of this section is on quality requirements regarding the conductof operations and tests in chemical/pharmaceutical, nonclinical and clinicaldevelopment. Regulatoryagencies of other regions have similar requirements. Have beea used r a longdine as remedies in the rmnnfnt ii disesdve vfistnrfaances andin a "jertadn nmnher of :3ses rie ippcdte remi ii b and patientsa lan number of bodies isoiared from piants wiiidi lunre thecommon chanictetfsnr? The time is given in hours along the horizontal line; the tem-perature in degrees centigrade on the vertical. This phenomenon ofsensitization is known as anaphylaxis.diphtheria antitoxine.diphtheria antitozine is obtained by immunizing horses withdiphtheria. The active principlesstand in no less buy drug ativan 2mg tablets online uk need of being assayed. buy drug ativan 2mg tablets online uk analysis of phase 3 clinical trial data showed nodifference in adverse events in patients taking tadalafil buy drug ativan 2mg tablets online uk with or without antihypertensive medicinalproducts. They are not welladapted order ativan 2mg in uk for organic diseases of this organ because of the irritationwhich they produce.ether and chloroform are used in the form of liniments ascounterirritants on the skin over diseased parts, such as rheumaticjoints. A very ancient use of silver oxide and more recently of thenitrate, is that in the treatment of epilepsy, chorea, tabes and variousother nervous diseases. Njihov se PR najviše oslanja na intuiciju pojedinaca, a ne na relevantne činjenice koje itekako utječu na njihovo svakodnevno poslovanje i funkcioniranje. Italso acts much more deeply buy generic lorazepam 2mg online with paypal than the members of the next divisionwhich are non volatile, and the inflammation caused by the formeris more difficult to cure than that of the latter. Nicotine thus first stimulates and thenparalyzes the ganglia on the course of the chorda tympani and of thesympathetic fibres supplying the purchase lorazepam 2mg in the uk online gland. Theseproperties can be expressed as differences in shape or size, po-larity and charge, lipophilicity, polarizability, or flexibility.19the cheap lorazepam in florida application of buy drug ativan 2mg tablets online uk molecular diversity techniques buy drug ativan 2mg tablets online uk to drug cheap lorazepam 2mg online in uk dis-covery is a lorazepam 2mg online legally multidisciplinary effort requiring the skills of peopleof varied backgrounds, ranging from computational chemistryto engineering to organic synthesis to molecular biology.20rational, or structure-based, drug design refers to a processthat begins with a high-resolution map to the active site of adisease target. The pulse becomes slow and irregular, the respirations slowand labored. The urine is often increased by the exhibition of ammonium salts,but not always. When a muscle is exposed, it isseen to contract as rapidly as usual, but instead of buy drug ativan 2mg tablets online uk immediately relax-ing again, it remains shortened and offers resistance to the contractionof the opposing muscles. Irritation of thestomach, or hyperacidity of buy drug ativan 2mg tablets online uk the gastric juice, is, of course, a contra-indication.acid may also be used to make the urine acid, and thus to render itless favorable to the growth of microbes. The carbonate of ammonia, when swallowed, also causesslight gastric irritation, and in larger quantities nausea and vomiting.after absorption buy drug ativan 2mg tablets online uk ammonia and its carbonates are rapidly changedto urea, and thus differ from the fixed alkalies in not increasing theavailable alkali of the blood, and in having no effect on the urine exceptto increase the urea and thereby cause some diuresis.the carbonate of ammonia stimulates the central nervous systemwhen it is injected into the blood in some quantity, but it has no sucheffect when absorbed from the stomach. If irritation is induced the vessels are dilated, andthere is no evidence that they are ever contracted in the practical useof acute silver poisoning from the ingestion of silver nitrate, thesymptoms are those of severe gastrointestinal irritation and corrosion.burning pain is felt in the throat and abdomen, and is followed bynausea and vomiting and often by purging. The clinical use of this compound,and of other central nervous system drugs, has resulted in amarked reduction in the number of mentally want to buy lorazepam with paypal ill patients need-ing hospitalization.research in the academic community has been supported toa major extent by agencies of the us government, such as thepublic health service (phs), the national institutes of health(nih), the centers for disease control and prevention (cdc),and the national science foundation (nsf). Although physical causes are now more readily diagnosed and treated, individual or marital counseling is still an effective treatment for impotence when emotional factors play a buy drug ativan 2mg tablets online uk role. In warmblooded animals, the heart stops paralyzed in diastole, but asmentioned before in the coldblooded, as the frog and turtle, itstops in buy drug ativan 2mg tablets online uk systole.the amount of vagus action varies considerably in differentindividuals. Arsenousanhydride is still used in dentistry to destroy the pulp in purchase ativan 1mg with mastercard decayed teeth;this destructive, caustic action proceeds more slowly than under moreviolent corrosives, so that there is little or no pain from it.internally arsenic buy drug ativan 2mg tablets online uk is used in malarial disease, buy drug ativan 2mg tablets online uk especially in invet-erate cases in which there is much cachexia. In addition to in vitrostudies, relevant biologic effects, drug metabolism, buy drug ativan 2mg tablets online uk pharmacoki-netic profiles, and particularly an assessment buy drug ativan 2mg tablets online uk of the relative safetyof the drug must be characterized in vivo in animals before humandrug trials can be started. Ironically, it is these very men who researched the female cheapest generic zolpiem in uk reproductive system and helped develop the branch of gynecology and obstetrics. The greatest constriction is seen in the vesselsof the splanchnic area, but most of the other vessels are also involvedin lesser degree. Dose: there are, however, two great objections which make this method impracticable,first, the greater shock on account of the buy drug ativan 2mg tablets online uk consciousness of thepatient, buy drug ativan 2mg tablets online uk and second, buy drug ativan 2mg tablets online uk the poisonous symptoms consisting of deurium, nausea, vomiting, headache and collapse which often followwhen cocaine is apphed in this way. Cross-study comparisons certainly cannot be used to make decisionsor estimate differences in drug products with the generally ac-ceptable sensitivity of difference detection of 20% or less. Facilities must be designed,constructed, and controlled to provide the proper stable envi-ronment for protecting the integrity of products. — 5.hezamethylenamina division.hezamethylenamina (u.), known under the trade names ofurotropine, uritone, cystogen, cystamine, formin, aminoform, buy drug ativan 2mg tablets online uk ammonioformaldehyde, composed of colorless crystal with bitter sweet taste, easilysoluble in water.helmitol and citrarin, white crystalline compounds of hezamethylenamina and dtric acid. When tablet is taken with a high fat meal, the rate of absorption is reduced, witha mean delay in tmaxof 60 minutes and buy drug ativan 2mg tablets online uk a mean reduction in cmaxof 29%. Difficile. The anaesthetic actionis, however, merely an instance of its general toxicity, for if broughtcocaine 357in contact with other forms of living matter in the concentration usedin anaesthetising nerve ends, it is poisonous to all the structures whichhave been examined. Chemical andpharmaceutical issues are rarely the cause of a decision to stop a drugdevelopment project. R-warfarin)tadalafil (10mg and 20 mg) buy drug ativan 2mg tablets online uk had no clinically significant effect on exposure (auc) to s-warfarin orr-warfarin (cyp2c9 substrate), nor did tadalafil buy lorazepam nashville affect changes in prothrombin time induced bywarfarin.aspirintadalafil (10mg and 20 mg) did not potentiate the increase in bleeding time caused by acetyl salicylicacid.antidiabetic medicinal productsspecific interaction studies with antidiabetic medicinal productswere not conducted.pregnancythere are limited data from the use of tadalafil in pregnant women. The symptoms in mammals are increasinglassitude and weakness, with augmented reflex excitability, tremors, and finallyconvulsions. Another factormay act in buy drug ativan 2mg tablets online uk this respect, i., the odor and taste of the pleasantvolatile buy drug ativan 2mg tablets online uk oils, which in a psychical way may improve the digestion;i54 locu. At the sametime, it has been the subject of much and laborious investigation,partly because it has frequently given rise to poisoning, and partlybecause the study of its effects has thrown much light on some physio-logical and pathological processes. To characterise the pharmacokinetic xanax 1.5mg discounted profile of a drug candidate single-dosepharmacokinetic studies are conducted in the animal species that will be usedin pharmacology and toxicology studies (e. This constriction isdue to direct eflfect on the muscle fibers.some evidence of medullary stimulation is seen in the slowingof the heart. The nerve terminations seem tobe unaffected even by very large quantities, so that as long as a con-traction of the muscles can be elicited by direct stimulation, it followsalso on stimulation of the motor nerve, and the vagus terminations inthe heart can transmit impulses as long as the heart continues to beat.the temperature is somewhat lowered by the nitrite series, owing tothe dilatation of the skin vessels, but this fall is insignificant.amyl buy drug ativan 2mg tablets online uk nitrite causes the blood to assume a dark chocolate color,both in the body and in the test-tube. Extracts of other organs, as thymus gland, testicles, ovaries,spleen, bone marrow and pituitary bodies, have been tried intherapeutics without much more than psychical effects.thymus gland buy drug ativan in singapore contains a principle which lowers blood pressureand causes death by collapse, when given in very large has been recommended in exophthalmic goitre, but withoutmuch effect.testicular extract was first recommended by browns6quardas a rejuvenator and has been used more or less since, althoughwithout any apparent effect. Among the major drugs discovered and/or developed in the united states during this period were in-sulin, buy drug ativan 2mg tablets online uk sulfonamides, penicillin and broad-spectrum antibiotics,cortisone and other steroid compounds, isoniazid, diuretics,and tranquilizers (now commonly referred to as anxiolyticsor antipsychotics). Digipuratum where to buy ativan 1mg in japan is said to contain the cardiac glucosides of theleaves in combination with tannin and freed from most of the inactive con-stituents. It is used as a stimulant and antiseptic in skin diseases, espedallyin psoriasis in 5 per cent, to buy drug ativan 2mg tablets online uk 10 per cent, solution and is best applied to the. The types of risks that may impede the success of a drug development projectare:- technical risks that are associated with where to buy lorazepam 1mg in thailand safety, efficacy and manufactura-bility (quality).- business risks that are not only associated with financial aspects but alsowith the safety and efficacy of drugs of the same pharmacological classfrom the competition already on the market or still in development.the risk in such a case may become so high that buy drug ativan 2mg tablets online uk a drug developmentorganisation may decide to abandon the project to prevent furthercosts and the drug to become third or fourth choice in the physicianstherapeutic arsenal. Instances of nausea, vomiting, tremor, irritability, or palpitation have also occurred. It also increases the heat dissipation sothat no rise of temperature is seen, but even a fall, buy drug ativan 2mg tablets online uk just asafter other convulsive agents. 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Cases of sudden decrease or loss of hearing have been reported postmarketing in temporal association with the use buy drug ativan 2mg tablets online uk of pde5 inhibitors, including. Training programsmust be thoroughly documented and include an evaluation ofmastery of the procedures employed.distribution departments are responsible for controlling theshipping and handling of products, using inventory-control sys-tems most often based on thefirst in–first outprinciple. It has thesame uses as acetanilid, but buy cheap ativan online in uk it is buy drug ativan 2mg tablets online uk a more buy drug ativan 2mg tablets online uk efiqicadous analgesic.methacetine buy cheap lorazepam 1mg online legally from canada contains one less methyl group than phenacetine. Cooperation is a major feature of today’s scientific in-vestigations. The injection is unattended bypain, irritation or any other symptom; the soluble hydrochloride isdissolved in the ordinary way. Health buy drug ativan 2mg tablets online uk arms you with the information you need to be an empowered patient and live your healthiest life. Even as the suspected medical causes for impotence are screened, patients will still need help to deal with the shame, embarrassment, and buy drug ativan 2mg tablets online uk the buy drug ativan 2mg tablets online uk relationship problems that can accompany their impairment, whether organically based or not. Albino rats severely impaired relative to pigmented strains. Do not take sildenafil (viagra) or vardenafil (levitra) for 24 hours before the test. Diuretic-induced hypokalaemia increasesthe toxicity of digoxin. On a global improvement question, 83% ofpatients reported improved erections on tablet versus 12% on placebo. The therapeuticequivalence evaluations in this publication reflect fda’s ap-plication of specific criteria to the approved multi-source pre-scription drug products. Dose: lorazepam 2mg prescription long term the abundant and fresh growth of the bacteriawas utilized for antimicrobial susceptibility tests.determination of antimicrobial susceptibility: in the case of ether orchloroform, when given by the open method not previously mixedin a tank order ativan 2mg online in uk with oxygen, they should be administered on a lightpermeable inhaler held some distance from the face while theeyes are kept closed to prevent their irritation. A diuretic is used to control symptomaticoedema and dyspnoea in patients with heart failure. Marked local irritation sometimes leading to cheap lorazepam in london vomiting and diarrhoea after internal administration. Consequently, tamoxifen may be useful not only inthe treatment and prophylaxis of breast cancer but also in buy drug ativan 2mg tablets online uk theprevention of osteoporosis by increasing bone density.lso create complications inpostmenopausal women, however, by exerting an agonist action inthe uterus, stimulating endometrial cell drug development is not confined to agents that act onreceptors for extracellular chemical signals. One of the most successful and enthusiastic has been crile of cleveland, who has used it in himdredsof cases for all sorts of major surgical operations, lasting, in somecases, over periods of hours, with most excellent results. In solution in caustic alkalies, it becomes changed buy drug ativan 2mg tablets online uk by the air to chrysophanic is used externally only as an irritant, antiseptic and antiparasitic in thetreatment buy ativan paypal of skin diseases, and especially in psoriasis and taenia as a 5 percent, ointment or collodion. In normal individualsand in animals the diuretic action is generally much weaker, althoughsome recent work has shown that it can be elicited easily in rabbits(cohnstein). Absolute bioavailability oftadalafil following oral dosing has not been determined.the rate and extent lorazepam 1mg prescription abuse of absorption of tadalafil are buy drug ativan 2mg tablets online uk not influenced by food, thus may be takenwith or without food. Propecia, merck, suggests that buy drug ativan 2mg tablets online uk it targets hair loss primarily on the top of the head (the middle front, and the top of the head). With this information, it is often possible to de-duce the entire structure of a molecule rapidly and precisely.x-ray crystallographic analysis enables the physical chemist todetermine the precise position of each atom of buy drug ativan 2mg tablets online uk a molecule as itexists in the crystalline form. However, with time,hepatic gsh is depleted faster than it can be regenerated, and areactive, toxic metabolite accumulates. In severe cases theserum may be injected intravenously; it has no action when taken bythe mouth.antitetanus serum.the tetanus bacillus forms a toxin which induces powerful tetanicspasms from an action on the spinal cord similar to that of strychnine.these buy drug ativan 2mg tablets online uk may be elicited by the injection of the toxin and also arisefrom its absorption from wounds infected with the bacillus. At 2 years, an increase in hair growthwas demonstrated in 66% of men treated withpropecia, compared with 7% of men treated withplacebo. Letter, the excitability of theventricle may be so great that it adopts its own regular rhythm (fig. In dogs vomit-ing and dilatation of the pupil generally occur.antifebrine is more poisonous than antipyrine in both frogs and mammals,but resembles it in its general effects, producing first a more or purchase meridia online canada less markedstage of lessened activity, followed by convulsive movements. Several other investigators have observed changes buy drug ativan 2mg tablets online uk inthe bones after phosphorus, so that there is good reason to believe thatit possesses some specific action on them, although some writers failedto obtain definite results and of those who observed a modification inthe growth no two agree in the description of the changes buy drug ativan 2mg tablets online uk or in theirinterpretation.5s0 substances acting after absorptionthis specific buy drug ativan 2mg tablets online uk action on the bone-forming tissues and particulariyon the periosteum may explain the necrosis of the jaw in matchfactories. As they became more physically distant, the quality of their marital relationship began buy drug ativan 2mg tablets online uk to deteriorate. The red-blood cells are found to bemuch shrunken, and haemorrhages are found in different organs; the lungsare (edematous, and the intestinal mucous membrane is swollen and congested.the salts of the urine are increased by diuresis from any cause, ashas been stated; both sodium where to purchase ultram in the uk online and potassium are augmented, but buy drug ativan 2mg tablets online uk espe-cially the sodium, which is present in larger proportions in the plasmaand therefore forms a larger constituent of the glomerular secretion.this increase in the sodium salts is, of course, particularly markedwhen diuresis is induced by common salt, but when potassium saltsincrease the urine, the sodium also generally predominates in it andthis would eventually lead to the loss of all the sodium in the bloodof herbivora, whose food contains large quantities of potassium; butafter a certain amount of sodium has been lost, potassium causes nofurther excretion, so that the tissues apparently protect themselvesfrom the total loss of sodium chloride, which would be fatal tothem.bunge states that in both man and animals a diet rich in potassium causesan appetite for common salt, while a diet which does not contain an purchase generic ativan online india excessof potassium does not develop this desire. In the cat the haemoglobin is not so largely formed intobile pigment, but escapes in the urine. This vie was contested by bunge who held that the therapeutic action could beexplained without assuming the absorption of iron. Is a vasodilator, a drug that has the effect of dilating the blood vessels.

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In 1882-3, kocher and reverdinpublished observations made on patients whose thyroids had beentotally extirpated, and who had subsequently presented a series ofsymptoms buy drug ativan 2mg tablets online uk to which these observers gave the name of cachexia thyreo-528 substances acting after absorption•priva. — 0. These invasive treatments are no longer necessary. It is more active when buy drug ativan 2mg tablets online uk applied todenuded surfaces and to the mucous membranes, destroying them tosome depth and causing cheapest generic lorazepam 1mg online in canada acute pain, but even here it acts more slowlythan ordinary caustics. The intellectbecomes brighter and the patient in due time becomes entirelynormal. The insight in microsomal metabolismcan be refined by comparing in vitro metabolism amongst several species andthe identification of the various cytochrome p450 enzymes involved in themetabolism of the selected molecules. Cerebrovascular — serious cardiovascular events, including myocardial infarction, sudden cardiac death, stroke, chest pain, palpitations, and tachycardia, have been reported postmarketing in temporal association with the use of tadalafil. Absorbed iron is changed to indissociauecompounds (ferratin), several of which have been must not be inferred from the foregoing that all of lorazepam 1mg prescription coupon the inorganiciron swallowed is taken up by the intestinal epithelium. buy drug ativan 2mg tablets online uk in the therapeutic use of these drugs the slowing is order ativan 1mg online in usa not greatin but slightly larger quantities, however, the inhibitory action causesa less complete contraction, so that the work done by the auricle isactually less than before the injection.the rhythm of the different parts of the heart is exactly the sameduring this stage, and the changes seen in the right auricle and ven-tricle correspond to those in the left.some observers state that small quantities of digitalis change theelectrocardiogram, in certain features, but these changes are not constantand have received no adequate explanation, so that they do not requirediscussion at present.if larger quantities be ativan with american express injected, either the inhibitory or the mus-cular action may buy drug ativan 2mg tablets online uk become markedly increased, and the appearance ofthe buy drug ativan 2mg tablets online uk heart varies according to which of these predominates. Thefailure of the respiration is the cause of death in buy drug ativan 2mg tablets online uk mammals, the heart con-tinuing to contract for some time longer. Very common (≥1/10); common (≥ 1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥ 1/10,000 to <1/1,000); very rare (< 1/10,000); and not known (cannot be estimated from the available data). If the dose has been sufficientlylarge, it changes into a deep coma with cyanosis of the mucousmembranes and skin, and the respirations become progressivelyfewer and shallower until they cease entirely. Other external applicationsare the plasters and the black and yellow wash. He'll make the other two eds listen to his sister, in fear of his parents wrath if he doesn't, and they of course can't really object. From the stimulation ofstriated muscle fibres, we observe fibrillary contraction of allskeletal muscles which may even last for a considerable time afterthe death of an animal poisoned by physostigmine. The treatmenthas to buy drug ativan 2mg tablets online uk be stopped immediately and the heart soon returns to buy drug ativan 2mg tablets online uk its numerous acute febrile conditions the heart becomes affected,possibly in part by the high temperature, but largely from the ativan to purchase online toxicproducts circulating in the blood. For example, theacetyl ester in aspirin is hydrolyzed to acetic acid and salicylicacid in the presence of moisture, but in buy drug ativan 2mg tablets online uk a dry buy drug lorazepam 1mg in the uk online environment thehydrolysis of aspirin is negligible. Illaccompanied by a diminution buy drug ativan 2mg tablets online uk in rate secondary to stimulationof the vagus, both centrally and buy drug ativan 2mg tablets online uk peripherally. Content that appears on this site comes from amazon services llc. Forinstance, when not more than one hundred grammes are givendaily to a man, it is all burnt except two per cent, which is foundin the urine. Dose normal, secure purchase, extra comps and discounts, fast delivery. Other combinations ofimmiscible phases could be given, but most heterogeneous systems encountered in pharmacy usually contain water. Subsequently, a sul-fanilamide product containing diethylene glycol as a solventto enhance the aqueous solubility of the drug was developed.diethylene glycol, however, is a highly toxic buy generic lorazepam 2mg no prescription agent used in anti-freeze solutions, and numerous deaths resulted from its inges-tion. Administration of w-acetylcysteine (the safer ofthe two) within 8-16 hours after acetaminophen overdosage hasbeen shown to protect victims from fulminant hepatotoxicity not effectivebecause it does not cross cell membranes readily.the dose and frequency of administration required to achieveeffective therapeutic blood and tissue levels vary in differentpatients because of individual differences in drug distribution andrates of drug metabolism and elimination. Buy drug ativan 2mg tablets online uk the formation of bile pigment from haemoglobinliberates large quantities of iron, which seems to be stored in buy drug ativan 2mg tablets online uk the liver, spleen,and bone marrow. The drug discovery cheap soma 350mg with paypal process is discussed in more detail in chapter 2. However, because of the economic investmentrequired and the need to efficiently access and integrate multipletechnologies, buy drug ativan 2mg tablets online uk most new drugs are then developed in pharmaceuti-cal buy drug ativan 2mg tablets online uk companies. These devices allow the penis to become erect and make sexual intercourse possible. Mean restingvalues for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressureand cardiac output decreased by 28%, 28%, buy drug ativan 2mg tablets online uk 20% and 7% buy drug ativan 2mg tablets online uk respectively. Remember, when you sense the tingle, the cold sore countdown is on. This treatment works to destroy much of the herpes virus, diminishing it's the growth and the potential to spread. In phthisis it should begiven with caution in order to avoid irritation of the stomach anddyspepsia, and in the presence of gastric catarrh from any cause, itseffects have to be watched carefully.some of the older authorities advise iron to be given in large quantities, but the dose has been reduced of late years to about o.log. In the last few years, this principle has beenfound in the colloid contents of the gland follicles in the form of aglobulin, thyreoglobulin, which may be extracted from buy drug ativan in singapore the colloidand gives the ordinary protein reactions, but is characterized by con-taining a small percentage of iodine; baumann's detection of thiselement in the thyroid gland was the first intimation that cheap lorazepam 2mg online legally from canada it existedin the tissues of the higher animals and man. Multidisciplinary teams are essential in industrialresearch requiring collaboration and effective communication;frequently a hundred or more scientists may be involved in dis-covering and developing a compound into a useful drug.some industrial research laboratories are organized accordingto scientific disciplines, such as departments of organic chemis-try or pharmacology. The effects of dexmedetomidine can beantagonized with a 2 -antagonist drugs. 10 mgs.chromic acid is used as a caustic application to malignant growths, chancresand diphtheritic membranes, to a less extent as an irritant antiseptic. (510 grains). For example, a team may decide to outsource the manufacturingof a new drug to a third party. This observation of withering was soon con-firmed by further experience in the use of this drug, but it was longdisputed whether this diuretic action occurred in health, or whether itwas not confined to cases in which pathological accumulations of fluidwere present. The nuclear magnetic field of the nuclei interactswith the very large magnetic field (10 000-50 000 g) of buy drug ativan 2mg tablets online uk the instrumentwhereby the nuclear magnetic field can reach a number of quantum states.the spin states that are oriented parallel to the external magnetic field arelower in energy than the spin states opposing the external field. The results show that the film coat-ing does not impart the degree of acid stability that the entericcoating does when the tablets are administered immediately af-ter food in a typical clinical situation. It is called vaccination and buy drug ativan 2mg tablets online uk was first introduced in connection with smallpox,when variolization was employed.

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